• Clinical manifestation and fatty acid balance in children with biliary dysfunction and iron deficiency 

Clinical manifestation and fatty acid balance in children with biliary dysfunction and iron deficiency 

PERINATOLOGIYA I PEDIATRIYA. 2016.2(66):116-121; doi 10.15574/PP.2016.66.116 
 

Clinical manifestation and fatty acid balance in children with biliary dysfunction and iron deficiency 
 

Marushko U. V., Nagorna K. I., Bryuzgina T. S.

Bogomolets National Medical University 
 

Objectives: to study the effect of iron deficiency (ID) on the clinical manifestation and erythrocytes, plasma and saliva fatty acids spectrum in children with functional disorders of the biliary tract (FDBT) 160 children 9–17 years old were examined who had been treated in hospital for FDBT exacerbation. According to the iron metabolism parameters children were divided into 3 groups: I — 29 children with FDBT and I-degree ID anemia; II — 91 children with FDBT and latent ID; III — 40 children with FDBT and normal iron metabolism tests.


Methods: the study of anamnesis, clinical examination, CBC, serum iron, TIBC indexes, percent transferrin saturation calculation, ultrasound of the abdomen and dynamic ultrasound cholecystography with choleretic breakfast, chromatographic analysis of erythrocytes, plasma and saliva fatty acid spectrum.


Results: it was found that ID children have an increase in the frequency and duration of FDBT

exacerbations, increased frequency of dyspeptic and asthenic-vegetative symptoms during exacerbation, decreased gallbladder motility and hypotonic-hypokinetic FDBT type. Changes in the erythrocytes, plasma and saliva fatty acid spectra were unidirectional in children with FDBT, and exhibited an increase in the fatty acid saturation. These changes were statistically significantly (p<0.05) more expressed in patients with ID.


Conclusion: Burdened course of FDBT is observed in children with ID due to increased frequency and duration of exacerbations, dyspeptic and asthenic-vegetative symptoms in the acute phase, minor bile ducts motility, as well as increased fatty acid spectra saturation in erythrocytes, plasma and mixed saliva, which indicates increased lipid peroxidation.


Key words: children, functional disorder of the biliary tract, iron deficiency, fatty acid spectrum, rythrocytes, plasma, saliva.


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