• Clinical course of rotavirus gastroenteritis in children younger than 5 years in recent times

Clinical course of rotavirus gastroenteritis in children younger than 5 years in recent times

SOVREMENNAYA PEDIATRIYA.2017.4(84):96-100; doi 10.15574/SP.2017.84.96

Chernyshova L. I., Teslenko M. Yu., Radionova N. M., Kasyan O. I.
Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine
Kyiv Municipal Children's Clinical Hospital No. 1, Ukraine

Objective. To determine the burden of rotavirus infection and to characterize the severity of clinical manifestations in children younger than 5 years.

Materials and methods. The study was conducted by standard protocol approved by the World Health Organization. Determining the severity of the disease was performed by using point scale assessing the severity of clinical manifestations of rotavirus gastroenteritis Vesikari.

Results and discussion. The study involved 218 children, rotavirus etiology confirmed in 92 (42.2%) cases. Genotyping was conducted in 34 samples of biological material. Children younger than 2 years of age accounted for 61.92% (57/92). Children were admitted to the hospital on the 1th — 7th day of illness

(Median 2 [IQR: 1–3]). At the time of admission, 72.83% (67/92) of them had vomiting and 82.67% (76/92) of children had fever. During the height of disease, the diarrhea was predominant on the frequency and duration. The clinical course of rotavirus gastroenteritis according to the Vesikari Score in most children was estimated as severe (14 points (2.86)). During 2015 in Kyiv were circulating simultaneously 8 genotypes, and the most common was Genotype G4P8

that made up to 50% (17/34). The latter caused severe clinical course according to the Vesikari Score.

Conclusions. Rotavirus infection characterized by severe clinical course in children younger than 5 years, and therefore, a large number of hospitalized patients. The significant burden of rotavirus infection in children of this age group proves the feasibility of universal vaccination.

Key words: rotavirus, Vesikari scale, genotypes, vaccination.

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