- Association of lactase gene polymorphism with dyslipoproteidemia in children with obesity
Association of lactase gene polymorphism with dyslipoproteidemia in children with obesity
SOVREMENNAYA PEDIATRIYA.2017.2(82):118-121; doi 10.15574/SP.2017.82.118
Abaturov A. E., Nikulinа A. A.
SI «Dnipropetrovsk Medical Academy of Health Ministry of Ukraine», Dnipro, Ukraine
Over the past 20 years, the incidence of children obesity has doubled and assumed paramount medical and social significance, but genetic factors of lipid metabolism disorders caused by alimentary intervention in childhood remain under-investigated.
Objective: To study the association of 13910 C> T gene lactase (LCT) polymorphisms with lipid metabolism disorders in obese children.
Material and methods. A genotyping of LCT gene in 44 children with various forms of obesity was performed. The serum lipids was investigated by using enzyme-colorimetric method with Friedewald's calculation.
Results. The association of genotype C/C 13910 LCT gene (p<0.05) with hypertriglyceridemia, the high level of very low-density lipoprotein and the downward change in Kerdo index was determined in obese children.
Conclusions. The association of genotype C / C 13910 LCT gene with dyslipoproteyidemia was proved in obesity children.
Key words: lactase deficiency, lactase gene polymorphism, dyslipidemia, obesity, children
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