• Association of lactase gene polymorphism with dyslipoproteidemia in children with obesity

Association of lactase gene polymorphism with dyslipoproteidemia in children with obesity

SOVREMENNAYA PEDIATRIYA.2017.2(82):118-121; doi 10.15574/SP.2017.82.118

Abaturov A. E., Nikulinа A. A.
SI «Dnipropetrovsk Medical Academy of Health Ministry of Ukraine», Dnipro, Ukraine

Over the past 20 years, the incidence of children obesity has doubled and assumed paramount medical and social significance, but genetic factors of lipid metabolism disorders caused by alimentary intervention in childhood remain under-investigated.

Objective: To study the association of 13910 C> T gene lactase (LCT) polymorphisms with lipid metabolism disorders in obese children.

Material and methods. A genotyping of LCT gene in 44 children with various forms of obesity was performed. The serum lipids was investigated by using enzyme-colorimetric method with Friedewald's calculation.

Results. The association of genotype C/C 13910 LCT gene (p<0.05) with hypertriglyceridemia, the high level of very low-density lipoprotein and the downward change in Kerdo index was determined in obese children.

Conclusions. The association of genotype C / C 13910 LCT gene with dyslipoproteyidemia was proved in obesity children.

Key words: lactase deficiency, lactase gene polymorphism, dyslipidemia, obesity, children
References:

1. Abaturov AE, Nikulinа AA, Demidenko YV. 2016. Clinical significance of excess lactose in the diet. Child Health. 1(69): 104-109. https://doi.org/10.22141/2224-0551.1.69.2016.73726

2. Hromnats'ka NM. 2014. Types of dislipidemia in children with metabolic syndrome. WiadLek. 67; 2 Pt 2: 306-10. PMid:25796855

3. Zelіnska NB. 2013. Obessity of metabolіc syndrome in children. Klіnіchna endokrinologіya that endokrinna hіrurgіya. 4(45): 62-72.

4. Zielinska NB, Rudenko NG, Rudenko OG. 2016. Statistically Analytical reference pediatric endocrinologist. State Establishment "Center of the Ministry of Health statistics medicine"; Kiev.

5. Karachentsov YI, Khizhnyak OO, Kazakov AV. 2015. Childhoodobesity. Company "SAM". H: 240.

6. Maidannyk VG, Khaytovych MV,Prokhorovich TP, Kashpurenko YU. 2014. Metabolic syndrome in children: current diagnostic algorithm. Ukrainian Journal of Pediatric Endocrinology. 2(10): 86-87.

7. Bullappa A, Harish BR, Mahendra BJ. 2016. Evaluation of anthropometric measurements of central obesity as screening tools in children: multi receiver operating characteristic analysis. Int J Community Med Public Health. 2017, Jan; 4(1): 251-255. https://doi.org/10.18203/2394-6040.ijcmph20164748.

8. Fall T, Ingelsson E. 2014, Jan 25. Genome-wide association studies of obesity and metabolic syndrome. Mol Cell Endocrinol. 382(1): 740-57. https://doi.org/10.1016/j.mce.2012.08.018. Epub 2012 Sep 3.

9. Nordestgaard BG, Langsted A, Mora S, Kolovou G. 2016, Jul 1. Fasting is not routinely required for determination of a lipid profile: clinical and laboratory implications including flagging at desirable concentration cut-points-a joint consensus statement from the European Atherosclerosis Society and European Federation of Clinical Chemistry and Laboratory Medicine. Eur Heart J. 37(25): 1944-58. https://doi.org/10.1093/eurheartj/ehw152. Epub 2016 Apr 26.

10. Martin RM, Patel R, Zinovik A. 2012. Filter paper blood spot enzyme linked immunoassay for insulin and application in the evaluation of determinants of child insulin resistance. PLoS One. 7(10): e46752. https://doi.org/10.1371/journal.pone.0046752.

11. Friedewald WT, Levy RI, Fredrickson DS. 1972. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972. 18: 499–502. PMid:4337382

12. Haugaard LK, Baker JL, Perng W, Belfort MB, Rifas-Shiman SL, Switkowski K, Oken E, Gillman MW. 2016, Sep 22. Growth in Total Height and Its Components and Cardiometabolic Health in Childhood. PLoS One. 11(9): e0163564. https://doi.org/10.1371/journal.pone.0163564.

13. Jolliffe CJ, Janssen I. 2007. Development of age-specific adolescent metabolic syndrome criteria that are linked to the Adult Treatment Panel III and International Diabetes Federation criteria. J Am Coll Cardiol. 49; 8: 891-898. https://doi.org/10.1016/j.jacc.2006.08.065; PMid:17320748

14. Kronenberg F, Paulweber B, Lamina C. 2016, Mar. Genomwide association studies on obesity: what can we learn from these studies. Wien Med Wochenschr. 166(3-4): 88-94. https://doi.org/10.1007/s10354-015-0429-7. Epub 2016 Jan 21.

15. Misselwitz B, Pohl D, Frühauf H. 2013. Lactose malabsorption and intolerance: pathogenesis, diagnosis and treatment. United European Gastroenterol J. 1(3): 151-159. https://doi.org/10.1177/2050640613484463

16. NICE clinical guideline CG181. 2015. Lipid modification: cardiovascular risk assessment and the modification of blood lipids for the primary and secondary prevention of cardiovascular disease https://www.nice. org. uk/guidance/cg181/evidence/lipid-modification-update-full-guideline-243786637. 24 October 2015.

17. Peplies J, Börnhorst C, Günther K, Fraterman A, Russo P, Veidebaum T, Tornaritis M, De Henauw S, Marild S , Molnar D, Moreno LA, Ahrens W. 2016. IDEFICS consortium. Longitudinal associations of lifestyle factors and weight status with insulin resistance (HOMA-IR) in preadolescent children: the large prospective cohort study IDEFICS. Int J Behav Nutr Phys Act. 13(1): 97. doi 10.1186/s12966-016-0424-4/3.

18. Diekmann L, Behrendt M, Amiri M, Naim HY. 2017, Jan. Structural determinants for transport of lactase phlorizin-hydrolase in the early secretory pathway as a multi-domain membrane glycoprotein. Biochim Biophys Acta. 1861; 1 Pt A: 3119-3128. doi 10.1016/j.bbagen.2016.10.016. Epub 2016 Oct 21.

19. Lissner L, Lanfer A, Gwozdz W. 2012. Television habits in relation to overweight, diet and taste preferences in European children: the IDEFICS study. Eur J Epidemiol. 27(9): 705–715. https://doi.org/10.1007/s10654-012-9718-2.

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