• Approaches of elimination in infants and young children with food allergy 

Approaches of elimination in infants and young children with food allergy 

 

PERINATOLOGIYA I PEDIATRIYA.2016.1(65):100-103;doi 10.15574/PP.2016.65.100 
 

Approaches of elimination in infants and young children with food allergy 
 

Shadrin O. G., Koval'chuk A. A., Dyukareva S. V., Gayduchik G. A., Chernega N. F.

SI «Institute of Pediatrics, Obstetrics and Gynecology NAMS of Ukraine», Kiev, Ukraine 
 

Objective – to explore the effectiveness of elimination arrangements and the use of milk formulas on the basis of extensive hydrolysis of cow's milk protein and amino acid formulas in infants with allergies to cow's milk proteins. 
 

Patients and methods. The study involved 18 children (12 boys and 6 girls) in the age from 1 month to 1 year with severe atopic dermatitis (index EASI>18 points), who were under artificial feeding. All children received therapeutic formulas which contain a significant (extensive) hydrolysis of the whey protein. To the diet of each child gradually was administered the formulas up to the 100% daily volume for 3–4 days. Then therapeutic formula was administered for 4 weeks in an amount which meets the needs of the child's age-old. Evaluation of the clinical efficacy of therapeutic formula was carried out on 7, 14 and 28th day after the full amount of power according to predefined criteria for assessing by 10-point scale (0 — no effect; 10 — an excellent effect) 1 time per week. 
 

Results. After applying of therapeutic formula with partial and deep hydrolysis of proteins the SCORAD and EASI indices of most children were significantly decreased. Due to the inefficiency of therapeutic measures in 4 patients with severe manifestations of malabsorption syndrome and the absence of positive dynamics of cutaneous manifestations was used amino acid formula. An amino acid mixture of 100% consisted of free amino acids and represented as a product of dry noodles and intended for the full nutritional care of children from birth. At the end of the study, in all children was noted positive dynamics of weight and body length, the EASI index dynamics (average severity), rated according to the SCORAD scale (estimate of prevalence and intensity eruptions, subjective symptoms by 10-point scale) with the calculation of SCORAD index. 
 

Conclusions. It is found that the use of formulas on the base of extensive hydrolysis of cow's milk protein and amino acid formulas in children with food allergy to cow's milk protein allergy and polyvalent allergy is highly effective and safe for treatment. 
 

Key words: children, food allergies, treatment, diet therapy. 
 

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